| 초록 |
Hydrogels have great potential in the biomedical field due to their structural similarity to the extracellular matrix (ECM), high water content. As the functionality and application fields diversify, the high mechanical performance of hydrogel is required. However, hydrogel's insufficient tissue adhesion and recovery properties are limit their use. Herein, we synthesized TEGDA-DOPA crosslinker (TDC), a dopamine-modified crosslinker, and used it to synthesize hydrogel adhesive. A reversible second network is formed through the intermolecular interaction of dopamine in TDC, and the hydroxyl group of dopamine enables form an adhesion. The AA-TD hydrogel shows 328% fracture elongation, 103.5 kPa tensile strength, 71.4 kPa lap shear strength with porcine skin, 94% resilience and immediate recovery to cyclic loading. Moreover, AA-TD hydrogel could improve wound healing, and AA-TD hydrogel could be degradable in 72 hours under physiological condition. |
