| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | The conjugation of PGC-1a-derived peptide and Gallic Acid enhances Antioxidant and Anti-aging. |
| 초록 | The skin as a largest heterogeneous organ of the human body is vulnerable to premature aging due to external stress. As the skin ages, wrinkles occur due to reduced cell proliferation and the denaturation of the extracellular matrix. Therefore, in this study, a peptide, (galloyl)2-KTPPTTP (Gal2-Pep) was synthesized by combining TPPTTP, and gallic acid (GA). Antioxidant activity was confirmed using DPPH and DCF-DA assays. The reactive oxygen species (ROS) scavenging activity of Gal2-Pep was more stable compared to GA alone; after four weeks at room temperature, its ROS scavenging activity remained higher than 50%. The present research study proved that Gal2-Pep increases the expression of PGC-1a to prevent oxidative stress and proves its potential for use in anti-aging application through decreasing the expression of matrix metalloproteinase-1 (MMP1) and increasing the expression of type I collagen. |
| 저자 | 김관우1, 이후민1, 박치후2, 김형식2, 허윤석1 |
| 소속 | 1인하대, 2옙바이오 |
| 키워드 | Peptide; Gallic acid; PGC-1a; Anti-aging; Anti-Oxidant |
