| 초록 |
Bioresponsive hydrogels are promising drug carriers as actively responding to the disease environment for optimal therapeutic efficacy. In this study, inflammation-responsive hydrogel was developed to achieve effective drug delivery at the inflammatory site. Peptide-based linkers which could be cleavable by cathepsins, were introduced to modified alginate to deliver drug only in the inflammation state. A chronic wound can be formed by excessive inflammation stage. The sequential transition from M1 to M2 macrophage in the local immune environment is critical for successful wound healing. Herein, JQ1 was loaded in the hydrogel to reprogram macrophage polarization via epigenetic modification. Hydrogels loading with JQ1 responded to M1 polarized macrophages rather than the resting state of macrophages and excessively released JQ1 suppressed inflammation. Ultimately, our system developed in this study can potentially be used in the wide biomedical application for targeting drug delivery. |
