| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Biomineral-Based Oxidative Stress Amplifying Agents for Cancer Therapy |
| 초록 |
Recently, intracellular oxidative stress has attracted much attention as a target for cancer-specific therapy. Compared to normal cells, cancer cells are known for elevated ROS levels. Therefore, the modulation of the ROS level in cancer cells has been a research target of great interest for cancer treatment. Herein, we describe a biomineral-based oxidative stress amplifying nanoparticle that can effectively kill the cancer cells through the Fenton-like reaction. Nano-hydroxyapatite doped with the catalytic metal elements that can induce the Fenton-like reaction was fabricated through an aqueous one-pot in situ process. Within cancer cells, this nanoparticle can amplify oxidative stress by elevation of the hydrogen peroxide level and the following Fenton-like reaction which generates hydroxyl radicals, one of the highly toxic ROS. This inorganic biomineral-based oxidative stress amplifying agent may find various applications in ROS-modulating cancer therapy. |
| 저자 |
이평화, 김혜정, 민경현, 이홍재, 정서영, 이상천
|
| 소속 |
경희대 |
| 키워드 |
Reactive Oxygen Species (ROS); Cancer therapy
|
| E-Mail |
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