| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1382 |
| 발표분야 |
고분자 |
| 제목 |
Self assembled nanoparticles for photodynamic therapy |
| 초록 |
Photodynamic therapy (PDT) involves two individual non-toxic components to induce selective photochemical destruction of tumor tissue by administration of the light of a specific wavelength that activates photosensitizing drugs. Hydrophobicity is the most distinct characteristic of porphyrin derivitives including protoporphyrin IX. This hydrophobicity leads the compound to poor solubility in aqueous condition which causes difficulties in parenteral administration. In order to overcome this problem, we conjugates glycol chitosan (GC) nanoparticles to protoporphyrin IX to improve its hydrophobicity. The photodynamic activity (photocytotoxicity) of these protoporphyrin conjugated GC nanoparticles was evaluated on B16F10 melanoma cells in comparison with the free drug; photocytotoxic efficiency is being evaluated by TUNEL and MTT. In terms of characterization properties, size of nanoparticles were measured, transmission electron microscopy image is also provided. The antitumor effect of GC-PPIX nanoparticle is improved by specific targeting using EPR effect which is one of distinct characteristics of tumor tissue and enhancing solubility of photosensitizer. Therefore, HGC nanoparticles have excellent potential carrier of PPIX and other photosensitizers. |
| 저자 |
전윤옥1, 남윤식1, 김종호1, 김광명1, 정서영2, 권익찬1
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| 소속 |
1한국과학기술(연), 2경희대 |
| 키워드 |
Photodynamic therapy |
| E-Mail |
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| 원문파일 |
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