| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1772 |
| 발표분야 |
생물화공 |
| 제목 |
Genetic engineering of industrially useful Streptomyces peucetius ATCC 27952 strains for the overproduction doxorubicin |
| 초록 |
Streptomyces peucetius subsp. caesius ATCC 27952 is the only organism reported to produce a clinically important chemotherapeutic agent doxorubicin (DXR), which is obtained commercially by the chemical conversion of the more abundant daunorubicin (DNR). Since DXR is expensive, the development of improved strains or processes for its production would be beneficial. Here we have constructed an integrative recombinant plasmid vector pSM3 and transformed in S. peucetius by PEG-mediated protoplast transformation method. The enhancement of production can be checked by HPLC analysis. |
| 저자 |
이희찬, 송재경, Sailesh Malla, 류광경
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| 소속 |
선문대 |
| 키워드 |
Streptomyces peucetius; doxorubicin; overproduction; recombinant plasmid
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| E-Mail |
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| 원문파일 |
초록 보기 |
