| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Preparation of quantum dot loaded micelles for in vivo imaging |
| 초록 |
Luminescent CdSe/ZnS QDs of red emission colors were synthesized and encapsulated with poly(ethylene glycol)-poly(D,L-lactide) diblock copolymer micelles to prepare water-soluble and biocompatible QDs micelles nanoparticles. PEG-PLA diblock copolymers were synthesized by ring opening polymerization of D,L-lactide in the presence of methoxy PEG as a macroinitiator. QDs were encapsulated with PEG-PLA polymers by solid dispersion method using chloroform. The resultant polymer micelles with QDs encapsulated were characterized by various analytical techniques such as UV-Vis measurement, light scattering, fluorescence spectroscopy, transmission electron microscopy (TEM) and atomic forced microscopy (AFM). The polymer micelles with QDs encapsulated were spherical and showed a diameter range of 20-150 nm with monodispersed size distribution. The encapsulated QDs were highly luminescent, which have the high potential for applications in biomedical imaging and detection. |
| 저자 |
이용규1, 홍석민1, 임정혁2, 민현수2, Elango Subramanyam2, 허강무2
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| 소속 |
1충주대, 2충남대 |
| 키워드 |
quantum dot; micelle; imaging
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| E-Mail |
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