| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Aqueous Solubilization of Paclitaxel Using Hydrotropic Block Copolymer Micelle |
| 초록 |
Poor water solubility of hydrophobic drugs has been serious problems for drug formulation and bioavailability. Many of solubilization methods have been suggested, but with limited successes. Recently, polymer micelle system has attracted much attention as a useful carrier system for various poorly soluble drugs due to its good stability and unique colloidal properties. Hydrotropic agents are used to enhance the water solubility of poor water soluble compound. And it has more effective ability with polymeric structure. In this study, we have designed a hydrotropic block copolymer system by ATRP, which consists of a hydrophilic poly(ethylene glycol) block and a hydrotropic poly(2-(4-vinyl benzyloxy)-N-picolylnicotinamide) and can self-assemble in aqueous media to form micelle. The enhanced water-solubility of paclitaxel by the synergistic effect of hydrotropic and micellar solubilization has been characterized and the release of paclitaxel from the polymer micelle has been observed. |
| 저자 |
민현수1, 허강무1, 이상천2, 박기남3
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| 소속 |
1충남대, 2요업기술(연), 3Purdue Univ. |
| 키워드 |
Hydrotropic block copolymer; pH-reponsibility; Polymer micelle; Paclitaxel
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| E-Mail |
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