| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
SYNTHESIS OF PH-RESPONSIVE HYDROTROPIC POLYMER MICELLE FOR SOLUBILIZATION OF PACLITAXEL |
| 초록 |
Many drugs have serious problems such as limit of bioavailability and formulation of drugs for their low water solubility. To enhance the water solubility of hydrophobic drugs, many approaches have been conducted. Polymeric micelle systems have been developed as a promising formulation for hydrophobic drugs. But, the low stability with increasing of drug loading and usage of indispensable organic solvent are still remained problem. Hydrotropic agents are often used to enhance the water-solubility of poorly water-soluble compounds and found to be more effective in their polymeric structures. In this study, a pH-responsive hydrotropic polymer micelle that consists of hydrophilic poly(ethylene glycol) and hydrotropic polymer block, poly(2-(4-vinylbenzyloxy)-N-picolylnicotinamide) was synthesized by atom transfer radical polymerization. The polymer micelle was characterized by 1H-NMR, TEM and light scattering measurements, and their solubilizing capacity for paclitaxel was evaluated. |
| 저자 |
민현수1, 이상천2, 박기남3, 허강무1
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| 소속 |
1충남대, 2요업기술원, 3Purdue Univ. |
| 키워드 |
Polymer micelle; pH-responsive polymer; Hydrotropic agent; Paclitaxel
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| E-Mail |
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