| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Multifunctional Nanoparticles Based on Hydrotropic Block Copolymer for Cancer Therapy and Imaging |
| 초록 |
Hydrotropic block copolymer was investigated as the potential carrier of the magnetic resonance imaging (MRI) agent and anticancer drug, paclitaxel (PTX). The results showed that PTX and oleic acid-coated superparamagnetic iron oxide nanoparticles(OA-SPIONs) were successfully loaded into the hydrotropic polymer micelle. The encapsulated PTX was released from the micelles in a sustained manner. From in vivo study, it was evident that PTX- and OA-SPION-loaded hydrotropic polymer micelle were selectively accumulated into the tumor site after systemic administration. As a consequence, hydrotropic polymer micelle might have a potential as multifunctional nanoparticles for cancer imaging and therapy. |
| 저자 |
윤홍열1, 최기영1, GURUSARMY SARAVANAKUMAR1, 김아영1, 김광명2, 박재형1, 권익찬2, 박기남3
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| 소속 |
1경희대, 2한국과학기술(연), 3purdue univ. |
| 키워드 |
micelle; magnetic resonance imaging(MRI); anticancer agent
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| E-Mail |
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