| 초록 |
The solubilizing ability of two hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using 13 poorly soluble drugs. Although solubility enhancements as high as ~1,000 to ＞10,000-fold were obtained with each of the hydrotropic agents, important differences were found between the two. DMBA is more hydrophobic and undergoes more extensive self association than DENA, as determined by vapor osmometry. As a result, DMBA is generally a more powerful solubilizer of hydrophobic drugs. DENA is more polar and its self association is essentially limited to dimer formation. The solubilizing properties of two hydrotropic agents DENA, and DMBA in polymeric form were investigated for their ability to solubilize five poorly soluble drugs with a wide range of hydrophobicity. |
