| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표10분) |
| 제목 |
Osteogenic induction of hMSCs using independent release of bFGF and BMP-2 from hydrogel patterned fibrous scaffolds |
| 초록 |
Drug-releasing electrospun nanofiber has been extensively developed as biomimetic three-dimensional (3D) scaffold in various cell or tissue-related studies for last decade. However, despite these efforts, only a few studies have reported on the realization of spatially patterned nanofiber scaffold capable of programmed release of multiple growth factors, which are essential to achieve spatio-temporal control of various cellular behaviors. In this study, we developed hydrogel micropattern-incorporated nanofiber scaffold with capability of independent spatial-temporal delivery of multiple growth factors. As a model system, bFGF and BMP-2 were immobilized onto nanofiber and within hydrogel micropatterns, respectively and the effect of their release behavior on osteogenesis of hMSC was investigated. |
| 저자 |
이현종, 박상필, 장은지, 한상원, 정의석, 고원건
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| 소속 |
연세대 |
| 키워드 |
osteogenesis; spartio-temporal control; micropatterned scaffold
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| E-Mail |
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