| 초록 |
Magnetic drug targeting should be safe and effective, i.e. particles capable of carrying the desired and releasing drug at a controlled rate. Since magnetic colloidal particles could in principle be a suitable vehicle their external-field responsiveness. In this study, nano-sized poly ε -caprolactone (PCL) particles, widely used as a biodegradable polymeric carrier containing magnetite were prepared employing emulsification-diffusion method and double emulsion method. This study focused on the development of the encapsulation process utilizing ethyl acetate as a dispersed solvent. The Key factors which affected the characteristics of magnetic PCL particles such as their emulsion stability and morphology were investigated. Also magnetic PCL particles such as their shape, size distribution were characterized by SEM, TEM, DLS. Magnetic hysteresis of magnetic pcl particles was investigated by VSM (vibrating sample magnetometer). |
