| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | A Vibrio-based microbial platform for accelerated lignocellulosic biomass refinery |
| 초록 | Since the efficiency of the microbial processis greatly affected by the inherent metabolic activities of hostmicroorganisms, it is essential to utilize a microorganism that can rapidlyconvert biomass-derived sugars. Here, we report a novel Vibrio-based microbial platform that can rapidly and simultaneouslyconsume major sugars in lignocellulosic biomass, faster than that by anypreviously reported microorganisms. We engineered Vibrio sp. dhg strain to have the heterologous xylose isomerasepathway and evolutionary optimized for its rapid xylose catabolism. Thereafter,simultaneous consumption of glucose, xylose, and arabinose was achieved bydisturbing the phosphotransferase system. Superior performance andapplicability of the generated strain were demonstrated by achieving efficientlactate production with high productivity and titer. We believe that thedeveloped strain can be broadly utilized to accelerate the production of diversebiochemicals from lignocellulosic biomass. |
| 저자 | 우성화1, 임현규1, 한용희2, 서상우2, 정규열1 |
| 소속 | 1포항공과대, 2서울대 |
| 키워드 | xylose; lignocellulose; Vibrio sp. |
