화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터)
권호 46권 2호
발표분야 의료용 고분자 부문위원회 Ⅰ,Ⅱ
제목 Preparation of the biocompatible and injectable polydimethylsiloxane microfiller using zwitterionic macromolecules
초록 Injectable silicone materials have drawn attention as minimally invasive bioimplants in a variety of biomedical fields. For the safe and effective use of silicone bioimplants, the body’s excessive fibrotic responses to hydrophobic silicone surfaces should be properly handled. In this study, the silicone microparticles were fabricated and in situ functionalized by a macromolecular surfactant, a copolymer composed of polar zwitterions and nonpolar alkyls, using a simple interfacial phenomenon. Successful synthesis and surface functionalization of the macromolecular surfactant were confirmed by 1H NMR and XPS, and the lowering of protein adsorption and the consequent fibrotic events in a rat model was demonstrated by microscopic examination in vitro and in vivo, respectively.
저자 이준범, 최정우, 홍광대, 서지훈
소속 고려대
키워드 injectable filler; silicone; zwitterionic polymer; antifouling; biocompatibility; foreign body reaction
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