| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
A Medusa-Like β-cyclodextrin with Maleic Anhydride Derivatives, A Potential Carrier for pH-Sensitive Drug Release |
| 초록 |
We developed a new pH-sensitive drug delivery carrier based on β-cyclodextrin (β-CD) and 1-methyl-2-(2'-carboxyethyl) maleic anhydrides (MCM). To optimize pH-sensitivity for controlled drug release, we synthesized five maleic acid amide derivatives and compared their degradability for the development of pH-sensitive biomaterials with tailored kinetics of the release of drugs. Based on these results, we selected MCM and the primary hydroxyl groups of β-CD were successfully attached to MCM residues to produce a medusa-like β-CD-MCM. The MCM residue was conjugated with cephradine(CP) with high efficiency (＞90%). More importantly, β-CD-MCM-CP responded to the small pH drop from 7.4 to 5.5 and released greater than 80% of the drugs within 0.5 h at pH 5.5. In addition, the inclusion complex between β-CD-MCM-CP and the adamantane derivative was formed by simple mixing to show the possibility of introducing multi-functionality. |
| 저자 |
송영준, 강선영, 이연
|
| 소속 |
서울대 |
| 키워드 |
Performance; Functionality; biomedical; Composition & Microstructure; biomaterial
|
| E-Mail |
|
