| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Effects of osteoinduction in hMSC by newly synthetic peptide(OP-5) derived from BMP-2 and its application with OP-5 conjugated PLLA for clinical use |
| 초록 |
Bone morphogenetic protein-2(BMP-2) was widely used in orthopedics and dental implant surgery but there are a variety of side effects including unwished bone formation, cancerous signaling process. To solve these problems, novel synthetic peptide (osteogenic peptide-5, OP-5) derived from BMP-2 was developed for clinical use. The OP-5 influence was evaluated by in vitro and in vivo assay compared with BMP-2. To optimize the osteogenic effects, it was conjugated onto electrospun fibers fabricated from poly(L-lactide). The peptide tightly attached to nanofibers and it was maintained at least 28 days, in vivo mouse calvarial defect model showed that OP-5 conjugated nanofibers could increase the bone regeneration and mechanical property similar to BMP-2 coated PLLA. Our results suggested that OP-5 can be used as new therapeutic agents for bone regeneration and OP-5 conjugated nanofibers might be a feasible method as guided bone regeneration for a dental and orthopeadic treatment. |
| 저자 |
권보선1, 김세희1, 심혜은1, 이진규2, 홍윤정3, 문지연3, 신흥수2
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| 소속 |
1우리들휴브레인, 2한양대, 3위노바 |
| 키워드 |
BMp-2; bone regeneration; synthetic peptide
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| E-Mail |
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