| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
RE-ORGA to Alleviate DHT-induced Male Baldness in Human Dermal Papilla Cells |
| 초록 |
Testosterone and dihydrotestosterone(DHT) that are affect hair loss. 5α-reductases are converting testosterone into DHT. In hair loss processes, TGF-β1, DKK-1, DHT/DHT-AR(androgen receptor) complex are key factors. RE-ORGA was extracted from natural ingredient to alleviate hair loss with less adverse effects. This study showed that RE-ORGA can induce proliferation of dermal papilla and regulate molecular signaling pathway. Western blot analysis treated with RE-ORGA showed lowered expression of 5α-reductases. From RNA-Seq their expression was also examined to be decreased in transcriptional levels. Log-scaled fold changes of SRD5A1,3 and Bax were -0.518, -0.253, -0.758. Androgen receptor and TFGB1I1, co-activator for androgen receptor, were also down-regulated. On the other hand Ptk2b that is negative androgen receptor regulator showed over-expression. These results showed that RE-ORGA could regulates hair loss induced by testosterone and DHT. |
| 저자 |
권보선1, 강명균2, 박대의2, 한형윤2, 심혜은1, 홍윤정3, 문지연3, 윤석주2
|
| 소속 |
1우리들휴브레인, 2안전성평가(연), 3위노바 |
| 키워드 |
hair loss; DHT; testosterone; natural ingredient
|
| E-Mail |
|
