| 초록 |
Here, we demonstrate a new, core-shell nanoparticulate composed of three different components: an outer lipid membrane, a polymeric interfacial layer, and a drug-loading aqueous core. This novel nanoparticulate is synthesized by a new, double emulsion synthetic protocol that overcomes the weaknesses of the conventional emulsion method. The physicochemical properties of nanoparticulates can be varied; for instance, we replaced the outer membrane compartments with several lipid molecules. In addition, the interfacial polymeric layer can be modified by adding either hydrophobic PLGAs or hydrophilic nucleic acids with higher biocompatibility. A variety of surface functionalizations can also be achieved including several unique characteristics such as surface multifunctionality and sustained drug (e.g., ovalbumin) release. We believe that such versatile nanoparticulates are promising in vivo carriers for medications against several infectious diseases. |
