| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Gold Deposited Iron Oxide/Glycol Chitosan Composite Nanoparticles for Diagnosis and Targeting Delivery. |
| 초록 |
A novel method for gold deposited iron oxide/glycol chitosan composite nanoparticles has been designed and characterized as a drug delivery system. Firstly, gold deposited iron oxide nanoparticles was prepared as a diagnosis probe based on the previous method. Gold deposited iron oxide/glycol chitosan complex was formed by ionic interactions between chitosan and gold nanoparticles and was freeze-dried to prepare gold-iron oxide/chitosan composite nanoparticles in the powdery state. During the formation of composite nanoparticles, doxorubicin, a model anti-cancer drug was loaded on the gold surface. FE-SEM and ELS were used to observe the size distribution and zeta-potential. With the formation of composite nanoparticles with chitosan, the stability of gold nanoparticles was improved significantly. Gold deposited iron oxide/glycol chitosan composite nanoparticles in this study can be utilized as a drug delivery system. |
| 저자 |
오근상1, 송병철1, 이범석2, 김상윤3, 조선행2, 육순홍4
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| 소속 |
1한남대, 2울산의과대, 3아산생명과학(연), 4이비인후과 |
| 키워드 |
Nanoparticles; Glycol chitosan; Electrostatic interaction
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| E-Mail |
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