| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Preparation and Drug Release of Doxorubicin Loaded Core/Shell Nanoparticles Using Molecular Imaging. |
| 초록 |
A novel preparation method for core/shell nanoparticles with iron oxide complexed lipid cores is designed and characterized. To form iron oxide complexed lipid core, the prepared Iron oxides by coprecipitation method were complexed and incorporated in lecithin lipid under vigorous stirring, and hydrophilized by pluronic F-68. To forms stabilized nanoparticles, the freeze-drying was performed in the presence of trehalose used as a cryo-protectant. Doxorubicin was loaded into the iron oxide complxed lipid core by electrostatic interaction before the formation of polymeric shell. ELS was used to observe the size distribution and zeta-potential. Fluorescence spectroscopy was used to measure the loading amount and the release pattern. Cryo-TEM and ELS measurements observed the formation of doxorubicin-loaded core/shell nanoparticles with iron oxide complexed lipid core. The core-shell nanoparticles in this study can be utilized as anionic drug delivery system for molecular imaging. |
| 저자 |
오근상1, 이희훈1, 정래훈1, 송지영1, 조선행2, 육순홍3
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| 소속 |
1한남대, 2한국화학(연), 3신약기반기술연구센터 |
| 키워드 |
Core/shell nanoparticles; molecular imaging; drug delivery
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| E-Mail |
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