| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Drug Release of Doxorubicin Loaded Core/Shell NanoparticlesFor pH-Sensitive Delivery |
| 초록 |
It was well known that the mean value of extracellular pH of human patients having various solid tumors is 7.06 with a full range of 5.7-7.8. Based on this, the drug release in the slightly acidic condition (pH＜ 6.0) is required for the release of anticancer drug at the tumor site. This study has been performed to evaluate the core/shell nanoparticles as a pH-sensitive delivery system for anticancer drug(doxorubicin). For the application of core/shell nanoparticles as a pH-sensitive delivery system for anticancer drug, Doxorubicin was loaded into the core/shell nanoparticles and the drug release behavior in response to pH change was observed. Considering the size distribution and pH-sensitive release behavior of core/shell nanoparticles, the efficient delivery of Doxorubicin at the tumor site can be expected. |
| 저자 |
정래훈1, 오근상1, 육순홍1, 이경은2, 한성식2
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| 소속 |
1한남대, 2고려대 |
| 키워드 |
Doxorubicin Loaded Core/Shell Nanoparticles; pH-Sensitive Delivery
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| E-Mail |
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