| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
FABRICATION OF HYALURONAN-BASE NANOFIBRILS BY COAXIAL ELECTROSPINNING |
| 초록 |
For several reasons, the electrospinning of nanofibrous mats comprised of biopolymers, such as hyaluronic acid (HA) has been difficult to achieve. In this study, HA-based nanofibers were fabricated via coaxial electrospinning with poly(ɛ-caprolactone) (PCL) as sheath and methacrylated HA as core. After photocrosslinking, the nanofibers were hydrolyzed into nanofibrils (NFs). The PCL sheath was then removed to obtain HA NFs. The methacrylation of HA was confirmed by 1H NMR. Morphology of nanofibers was evaluated by scanning electron microscopy (SEM) and the sheath/core structure of nanofibers was confirmed by transmission electron microscopy (TEM). Swelling behavior and biodegradability was also determined. Furthermore, the formation of NFs/cell complexes and the proliferation of cells were investigated. |
| 저자 |
Vu Nguyen Oanh Pham, Wei Mao, 신지운, 이주원, 박재근, 유혁상
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| 소속 |
강원대 |
| 키워드 |
Hyaluronic acid; nanofibrils; nanofibers; electrospinning
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| E-Mail |
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