| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Enhanced Stability of Core/Shell Nano-particles with Lecithin Lipid Cores by Photo-Polymerization |
| 초록 |
Photo-crosslinked core/shell nanoparticles were achieved using lecithin nanolipids and di-acrylated pluronic F 127 by photo-polymerization without using an organic phase. These nanoparticles showed more dramatic thermo-reversible size change as compared to unmodified core/shell nanoparticles. The stability of photo-crosslinked core/shell nanoparticle was clearly enhanced as compared to unmodified system either in organic co-solvent or serum (FBS). Lysozyme could be loaded into the photo-crosslinked nanoparticles simply by incubating at 4 °C with a higher capacity (＞30%) than uncrosslinked core/shell nanoparticles. Protein release profiles from the photo-crosslinked nanoparticles showed more sustained release than uncrosslinked core/shell nanoparticles. Acknowledgement; This research was supported by the Research Center for Biomolecular Nanotechnology at GIST, and also partially by a grant from ‘Intelligent DDS’ of the Ministry of Science and Technology, Korea. |
| 저자 |
최원일1, 태기융1, 김영하1, 육순홍2
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| 소속 |
1광주과학기술원 신소재공학과, 2한남대 |
| 키워드 |
core/shell nanoparticles; lecithin; DA-PF 127; photo-polymerization
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| E-Mail |
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