| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
VEGF-loaded core/shell nanoparticles for the angiogenesis and the treatment of ischemic damages. |
| 초록 |
VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells. In our previous study, the core/shell nanoparticles with a lecithin lipid core were prepared and characterized as a delivery system for lipophilic drugs and VEGF. A further study has been also performed to evaluate the core/shell nanoparticles as a protein delivery system in vivo. In this study, their release behavior and the stability were investigated to evaluate the efficacy as a protein delivery system. From the release behavior of nanoparticles, a sustained release pattern was observed that releasing about 80% of the initial loading amount during a 42-day period. From the in vivo animal study, the nanoparticles with 0.25 of the lecithin/F-127 (w/w) ratio were observed better angiogenesis than other groups. The core/shell nanoparticles in this study can be utilized as sustained delivery system of VEGF to treat an ischemic damage. |
| 저자 |
이희훈1, 오근상1, 육순홍1, 윤소정2, 박용두2
|
| 소속 |
1한남대, 2고려대 |
| 키워드 |
vegf; core/shell
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| E-Mail |
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