| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hypoxia-responsive Polymeric Nanoparticles Based on Carboxymethyl-dextran for Cancer Therapy |
| 초록 |
Hypoxia is a hallmark of various intractable diseases. Herein, we have developed self-assembled nanoparticles which can selectively release the hydrophobic drug in response to hypoxic conditions. To prepare hypoxia-responsive amphiphilic nanoparticles (HR-NPs), hydrophobically modified 2-nitroimidazole (NI) derivative was conjugated to the backbone of carboxymethyl dextran (CM-Dex). Doxorubicin(DOX) as an anticancer drug was encapsulated into HR-NPs. The drug release behavior of DOX from HR-NPs shows significantly high release rate under hypoxia condition, whereas the HR-NPs released DOX in a sustained manner under the normoxic condition (physiological condition). Based on in vitro cytotoxicity tests, HR-NPs show higher toxicity to hypoxic cells than to normoxic cells. From the in vivo biodistribution and therapeutic efficacy tests, it is demonstrated that DOX-loaded HR-NPs have the capability for effective delivery of drugs into hypoxic cells as well as high anti-tumor activity. |
| 저자 |
Thavasyappan Thambi, 손소영, 윤홍열, 한화승, 박재형
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| 소속 |
성균관대 |
| 키워드 |
Hypoxia; Nanoparticles; Drug delivery; Bioreduction
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| E-Mail |
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