| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표10분) |
| 제목 |
Robust Mineralized PEGylated Hyaluronic Acid Nanoparticles as Carrier for Cancer Therapy |
| 초록 |
Self-assembled hyaluronic acid (HA), nanoparticles have received attention as promising drug carriers for cancer therapy.Because HA can bind to CD44, a receptor over-expressed on various tumor cells, recent studies have focused on pharmaceutical applications of HA as drug carriers However, a major problem interrupting HA-based drug carriers in attaining the efficient therapy lies in their inability to overcome the preferential accumulation at the liver site. In this study, we prepared mineralized PEGylated hyaluronic acid nanoparticles (M-PEG-HA-NPs)using a PEGylated HA derivative in the presence of calcium nitrate and ammonium phosphate. The physicochemical characteristics of the mineralized nanoparticles were investigated using transmission electron microscope (TEM), dynamic light scattering (DLS), FT-IR spectroscopy, and zeta-potential analyzer. |
| 저자 |
한화승, G. Saravanakumar, 윤홍열, 유동길, 고혜원, 엄우람, 손소영, 박재형
|
| 소속 |
성균관대 |
| 키워드 |
Mineralization; Hyaluronic Acid; Nanoparticles; Stability
|
| E-Mail |
|
