| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Stiffness Modulation of Polymeric Nanoparticles for Enhanced Detection of Influenza Virus via Viral Fusion Activity |
| 초록 |
Virus detection based on membrane fusion mechanisms has been achieved using nanomaterials with host-mimetic membranes or selective membrane fusion activity. Most research has been on designing functional nanoparticles with fusogenic capability, and there has been little exploitation of the mechanical characteristics of such nanoparticles to alter their fusion activity and improve their sensing performance. In this study, a fluorescent assay using polymeric nanoparticles (PNPs) with tunable morphology and stiffness is developed for rapid and straightforward detection of an activated influenza A virus. The particle stiffness can be readily controlled by varying the fraction of hydrophilic segments in block copolymers, giving rise to stiffness-dependent fluorescence. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through stiffness modulation for direct and sensitive identification of infectious viruses. |
| 저자 |
박채원1, 임종우1, 박근선1, 김현욱2, 이소정1, 송대섭3, 김은정4, 함승주1
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| 소속 |
1연세대, 2강원대, 3고려대, 4인천대 |
| 키워드 |
mechanistic analysis; influenza virus detection; polymeric nanoparticle; host-cell-mimic system; viral fusion
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| E-Mail |
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