| 학회 |
한국화학공학회 |
| 학술대회 |
2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 |
28권 1호, p.1261 |
| 발표분야 |
[주제 12] 화학공학일반(부문위원회 발표) |
| 제목 |
Productgion of ACE2-derived peptides in E. coli for the inhibition of spike glycoprotein of SARS-CoV-2 |
| 초록 |
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly transmissible and pathogenic coronavirus that emerged in late 2019 and is closely related to severe acute respiratory syndrome coronavirus (SARS-CoV) occurred in 2003. SARS-CoV-2 has spike (S) glycoproteins exposed on surface of viruses similar to SARS-CoV that bind to human angiotensin-converting enzyme 2 (ACE2), which play a key role in the cell entry phase. In this study, we designed ACE2-derived peptides mimicking the binding site of ACE2 with S glycoprotein with affinity tags and linkers. The ACE2-derived peptides were produced in E. coli and purified. Their inhibitory effects were evaluated by performing neutralization assay and ELISA to compare the inhibitory effects. The most effective ACE2-derived peptides have potential for the application of inhibitors. |
| 저자 |
이수빈, 박태현
|
| 소속 |
서울대 |
| 키워드 |
생물화공(Biochemical Engineering) |
| E-Mail |
|
| 원문파일 |
초록 보기 |
