| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Fabrication of antigen associated poly(lactic-co-glycolic acid) nanoparticle for house dust mite allergy |
| 초록 |
Allergic diseases are growing health concern, and immunotherapy for certain allergens is considered the only fundamental treatment for allergic diseases. The most widespread immunotherapy is a long period of dose escalation with a soluble antigen. Thus, a safer and efficient method is required to enhance the treatment of allergic diseases. In this study, a biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticle associated with allergenic antigen was developed, and the house dust mites extract was used as an antigen against the house dust mite allergy. We fabricated two different types of PLGA nanoparticles. The first type was the PLGA nanoparticle coated with the antigen, and another was the PLGA nanoparticle-containing the antigen. We compared the effect of the location of the antigen on the release profile. |
| 저자 |
이윤복, 강예영, 공민선, 김서영, 이현종, 이예린
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| 소속 |
가천대 |
| 키워드 |
PLGA nanoparticle; Der.P1 Protein; House dust mite; encapsulation; conjugation
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| E-Mail |
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