| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
대학원생 구두발표(토론II): 감염병 대응을 위한 생체 물질 전달용 고분자 연구 |
| 제목 |
Development of safe and efficient lipid nanoparticles (LNP) including biodegradable ionizable lipid |
| 초록 |
The development of vaccine has become a hot topic during the Pandemic of SARS-COV-2. In particular, mRNA vaccines and lipid nanoparticles that deliver mRNA are actively under investigation. Lipid nanoparticle (LNP) technology has been widely used as a delivery platform to facilitate the delivery of mRNA to target tissues or cells. However, the ionizable lipids developed in the early days had a toxicity issue due to its long half-life. Here, we have synthesized and developed an ionizable lipid (EZ4) containing biodegradable functional groups to lower the toxicity. EZ4 showed a good transfection efficiency to strongly express target protein compared to conventional ionizable lipids when injected through intravenously (IV) and/or intramuscularly (IM). Moreover, it showed low toxicity both in vitro and in vivo. EZ4 has shown great potential for the development of new generation of biodegradable ionizable lipids. |
| 저자 |
이예지, JEONG MICHAELA, 김민정, 이혁진
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| 소속 |
이화여자대 |
| 키워드 |
mRNA vaccine; LNP; ionizable lipid
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| E-Mail |
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