| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Emission Conduct of Sibtramine HCL Tablet with the Additives |
| 초록 |
In this study, sibutramine HCL, appetite suppressants were prepared into tablet type with additives such as lactose monohydrate, microcrystalline cellulose(MCC), and PVP K-25 to effective oral administration. We used the polyplasdone XL-10 as disintegrant. We compared the in vitro release behavior of sibutramine from the tablets according to additives with commercial drug, Reductil. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter(DSC). FT-IR and dsc results demonstrates that structure of drug was changed and crystallinity of drug was decreased according to additives. The dissolution rate of sibutramine HCL from tablet greatly increased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) in case of adding lactose monohydrate and PVP K-25. |
| 저자 |
오명준, 이은용, 정수미, 김은영, 조한수, 조원형, 송병주, 홍동현, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Sibutramine HCL; direct compression; tablet; excipient
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| E-Mail |
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