| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
hMSC-based immunomodulatorfor cancer therapy |
| 초록 |
Cytokine-basedimmune system activation requires high doses of cytokine to retain an appropriatelevel in vivo, thereby side effects such as cytokine storm may occur. Toovercome this limitation, we developed reactive oxygen species (ROS) produciblehuman mesenchymal stem cells (hMSC) for targeting tumor and locally secreting cytokine.We labeled the stem cell surface with polymer and photosensitizer (PPS) throughclick chemistry (PPS-hMSC). PPS-hMSC migrated to the tumor site by homing effectof hMSC, and pro-inflammatory cytokines such as heat shock protein 70 (Hsp70), IL-6,IL-8 are released from hMSC damaged by ROS under laser irradiation. These cytokinesinduce production and maturation of immune effector cells (IEC) such as T cell,natural killer cell (NK cell), B cell and antigen presenting cell (APC). Taken together,PPS-hMSC can be a potential agent being able to promote anti-tumor responses andtumor growth inhibitor for local immunotherapy. |
| 저자 |
김영아, 김경섭, 이주영, 한지은, 황희석, 이종환, 나건
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| 소속 |
가톨릭대 |
| 키워드 |
cancer immunotherapy; human mesenchymal stem cell; photodynamic therapy
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| E-Mail |
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