| 초록 |
Injectable silicone materials have drawn attention as minimally invasive bioimplants in a variety of biomedical fields. For the safe and effective use of silicone bioimplants, the body’s excessive fibrotic responses to hydrophobic silicone surfaces should be properly handled. In this study, the silicone microparticles were fabricated and in situ functionalized by a macromolecular surfactant, a copolymer composed of polar zwitterions and nonpolar alkyls, using a simple interfacial phenomenon. Successful synthesis and surface functionalization of the macromolecular surfactant were confirmed by 1H NMR and XPS, and the lowering of protein adsorption and the consequent fibrotic events in a rat model was demonstrated by microscopic examination in vitro and in vivo, respectively. |
