| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Therapeutic targeting of tetraspanin8 in epithelial ovarian cancer invasion and metastasis |
| 초록 |
Epithelial ovarian cancer (EOC) invasionand metastasis are complex phenomena that result from the coordinated action ofmany metastatic regulators and must be overcome to improve clinical outcomesfor patients with these cancers. In this study, we found that tetraspanin 8(TSPAN8) is overexpressed in about 52% of EOC tissues and correlates with poorsurvival. We identified TSPAN8–LEL as a key regulator of EOC cell invasion.Furthermore, monotherapy with TSPAN8-blocking antibody we developed shows thatantibody-based modulation of TSPAN8–LEL can significantly reduce the incidenceof EOC metastasis without severe toxicity in vivo. Finally, we demonstratedthat the TSPAN8-blocking antibody promotes the internalization and concomitantdownregulation of cell surface TSPAN8. Collectively, our data suggest TSPAN8 asa potential novel therapeutic target in EOCs and antibody targeting of TSPAN8as an effective strategy for inhibiting invasion and metastasis ofTSPAN8-expressing EOCs. |
| 저자 |
이지현1, 신하경1, 최혜림1, 이희언1, 박창식2, 이석묵1
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| 소속 |
1국민대, 2스크립스 코리아 |
| 키워드 |
therapeutic antibody; tetraspanin8; epithelial ovarian cancer; invasion; metastasis
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| E-Mail |
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