| 초록 |
Bone is a complex tissue with unique properties such as high strength and regeneration capabilities while carrying out multiple functions. However, large bone defects caused by critical size defect fractures, tumor excision and non-union are remained as a clinical challenge. In recent, combination of various growth factors and biocompatible scaffolds have been widely investigated for advanced new bone formation. In this study, we developed microparticles with leaf-stacked structure throughout entire particle (LSS particles) which can allow sustained release of the growth factor [i.e., bone morphogenetic protein-2 (BMP-2)] as well as enhance bone regeneration due to their unique morphology. The morphology, growth factor release behavior, cell [human periosteum-derived cells (hPDCs)] adhesiveness/proliferation/differentiation and bone regeneration using beagle dog animal model of BMP-2-immobilized LSS particles were investigated. |
