| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Development of GBR Membrane for Simultaneous Reconstruction of Bone and Epithelium |
| 초록 |
Recent studies related with GBR membrane have focused on exclusion of rapidly growing non-osteogenic cells into the bone defect for effective bone regeneration. Although it is well-established that the GBR membrane can accelerate new bone formation, a high risk of infection caused by loosening between membrane and epithelium remains as a clinical challenge. Many surgeons continue to raise the need for development of GBR membrane which can induce simultaneous reconstruction of bone & epithelium. In this study, we developed a film with leaf-stacked structure (FLSS) on both faces. It was expected that the FLSS allow sustained release of BMP-2 and PDGF-BB from each surface, and thus achieve effective regeneration of bone (by BMP-2) and epithelium (by PDGF-BB) on both sides, respectively. The morphology, physical properties, growth factor release pattern and cell behavior (adhesive/migration/differentiation) of growth factors-loaded FLSS were investigated. |
| 저자 |
김한별1, 김민지1, 변준호2, 이진호3, 오세행1
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| 소속 |
1단국대, 2경상대, 3한남대 |
| 키워드 |
Complex tissue regeneration; BMP-2; PDGF-BB; PCL film; GBR membrane
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| E-Mail |
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