| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.721 |
| 발표분야 |
재료 |
| 제목 |
Simultaneous Detection of Epidermal Growth Factor Receptor Mutations using Fluorescence Resonance Energy Transfer |
| 초록 |
Epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 are important factors to predict the response of tyrosine kinase inhibitors. We developed a novel method that allows simultaneous detection of mutations in both exon 19 and exon 21 of EGFR using FRET phenomena between two types of quantum dots and gold nanoparticles. We detected the presence of mutant type DNA of exon 19, or exon 21 or both from the change in photoluminescence intensity of suspensions. |
| 저자 |
이호섭1, 강태경1, 최동철1, 주상우2, 이소영3, 윤경아4, 이강택1
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| 소속 |
1연세대, 2숭실대, 3서울대, 4국립암센터 |
| 키워드 |
EGFR; FRET; Simultaneous
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
