| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.740 |
| 발표분야 |
재료 |
| 제목 |
Role of surfacecharge of mesoporous silica particles in drug delivery |
| 초록 |
We investigate the role of surfacecharge mesoporous silica particles in drug delivery. First, we prepare MCM-41 type mesoporous silica particles and control their surfacecharge through functionalization with organosilanes that have different functional groups. We use quasi-elastic light scattering (QELS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen sorption, and zeta potential measurements to characterize the synthesized particles. To use these particles as drug carrier for oral administration, ibuprofen is chosen as a model drug and ibuprofen loading and release characteristics of the particles with different surfacecharge are compared. These results suggest that electrostatic interaction between drug and particle surface plays an important role in drug loading and delivery. |
| 저자 |
김아름1, 이강택1, 이덕규2, 이호섭1, 황대현1, 이상훈3, Zhijian Wu4
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| 소속 |
1연세대, 2한미약품, 3Korea Institute of Energy Technology Evaluation & Planning, 4Huaqiao Univ. |
| 키워드 |
mesoporous; silica; surface charge; ibuprofen; loading; release
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| E-Mail |
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| 원문파일 |
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