| 초록 |
In this strategy, graphene oxide (GO) is covalently functionalized with a cationic biocompatible polymer through the simple synthetic process. We design a combinational therapeutics of the antibiotic drug and synthetic RNA and demonstrate its synergistic effect in vitro and in liver cancer cell xenograft mouse model representing Hepatitis C virus infection. We find that our strategy successfully improves the therapeutic efficacy by suppressing the tumor growth through enhancing intracellular accumulation of antibiotic drug with one tenth of conventional dosage and inhibiting replication of viral RNA at the molecular level through small interfering RNA (siRNA)-mediated sequence specific messenger RNA (mRNA) cleavage. By facilitating the combination of individual pharmacological effect, the present biocompatible polymer and GO-based delivery system could be a promising multimodal therapeutic platform due to high stability, biocompatibility, and multiple functionalities. |
