| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
A Protease-Activatable Polymersome for the Diagnosis and Treatment of Cancer Metastasis |
| 초록 |
Metastasis-associated proteases, such as MT1-MMP, play decisive roles during malignancy and have been used as biomarkers for diagnosis, prognosis, and drug targeting. Proteases-activatable polymersomes have great potential as cancer theragnosis platform due to the high selectivity of the activating proteases. Here we report a highly modular design for the efficient and simple synthesis of amphiphilic block polymer-peptide and copolypeptide based on methoxy-poly (ethyleneglycol)-b-polyleucine (mPEG-b-pLeu) and MT1-MMP antagonist peptide-b-polyleucine (MT1-peptide-b-pLeu), respectively. These amphiphilic self-assemble in water into polymersomes that can disassemble and release encapsulated imaging agent, gene and drug upon enzymatic activation. Importantly, this system was found to prevent the initiation and progression of cancer metastasis. Consequently, this study may also provide new strategy in the development of nanomedicine for diagnosis and therapy of cancer metastasis. |
| 저자 |
김현욱1, 최지혜2, 이훈재1, 노일구3, 임종우1, 윤다연1, 김지혜1, 천해진1, 박근선1, 함승주1
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| 소속 |
1연세대, 2Stanford Univ., 3KAIST |
| 키워드 |
Metastasis; MT1-MMP; Polymersome; Protease; Theragnosis
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| E-Mail |
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