| 초록 |
Chemoimmunotherapy based on the combination of anticancer agents and immune modulators is considered a promising anticancer therapeutic approach that leads to tumor cell death and tumor-specific immune responses, suppressing the growth of metastatic tumors in distal sites. This study aimed to design an amphiphilic triblock copolymer-based dissolving microneedle (MN), which can generate nanomicelles containing a poorly water-soluble anticancer drug, paclitaxel (PTX), and an immune modulator, resiquimod (R848), resulting in the death of metastatic tumor cells and the activation and maturation of DCs.The MN-mediated lymphatic delivery of an anticancer drug and immune modulator may be considered as a promising approach for chemoimmunotherapy of metastatic tumors. |
