| 초록 |
The development of biomaterial-based immune niches that can modulate immunosuppressive factors in tumor microenvironment will be a key technology for improving current cancer immunotherapy. Here, implantable, engineered 3-dimensional porous scaffolds were designed to generate synergistic action between myeloid-derived suppressor cell-depleting agents, which can accommodate the establishment of a permissive immunogenic microenvironment to counteract tumor-induced immunosuppression, and cancer vaccines consisting of whole tumor lysates and nanogel-based adjuvants, which can generate tumor antigen-specific T cell responses. The local peritumoral implantation of the synthetic immune niche as a post-surgical treatment in an advanced-stage primary 4T1 breast tumor model generated systemic anti-tumor immunity and prevented tumor recurrence at the surgical site as well as the migration of residual tumor cells into the lungs, resulting in 100% survival. |
