| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
분자전자 부문위원회 Ⅰ |
| 제목 |
Modulation of Tumor Microenvironment by a Designer Scaffold with Immune Checkpoint Blockade Enhance Cancer Immunotherapy |
| 초록 |
Regression of malignant tumors after post-surgical removement remains a clinical obstacle. Immune checkpoint blockade (ICB) implementation to overcome this obstacle by eliciting durable antitumor responses still holds limitation of low efficiency, which is due to fortified pro-tumoral environment after surgery. Here a promising platform, designer scaffold loaded with immune nanoconverters encapsulated with resiquimod (iNCVs (R848)) and doxorubicin, is introduced to polarize the immunosuppressing cells such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) to antigen-presenting cells (APCs), and simultaneously ameliorating antitumor response with low systemic toxicity, forming immunogenic TME. Along with TME modulation, duration of memory T cells specific to neoantigen prevents tumor recurrence and metastasis. Introduction of the spatiotemporal modulating designer scaffolds suggests immunogenic therapy that overcomes current limitations. |
| 저자 |
박세현, 김현지, Hathaichanok Phuengkham, 송찬영, 임용택
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| 소속 |
성균관대 |
| 키워드 |
Designer scaffold; nanoconverter; immune checkpoint inhibitor; in situ cancer vaccine; spatiotemporal control; cancer immunotherapy
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| E-Mail |
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