| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation and Evaluation of Tropolone-loaded in chitosan nanoparticles |
| 초록 |
Tropolone has been widely used as food additive. However, utilization of tropolone as preserved agent has been limited because of short half-life. To overcome these obstacle, tropolone was loaded in chitosan-graft stearic acid micelle (CSA). Then tropolone lead to sustained release. The chemical structure of CSA was analyzed by 1H-NMR. Moreover, tropolone loaded CSA nanoparticles (CSAT) were prepared by evaporation method. The contents, encapsulation efficiency and release behavior of tropolone from CSAT were confirmed by UV-vis spectrophotometer. The particle size and morphological property of CSA and CSAT were confirmed by DLS and TEM. Moreover, cytotoxicity of CSA and CSAT were confirmed by MTT assay in HEK 293 cell line. These results suggest that CSA micelle is exceptional drug carrier for sustained release of tropolone. |
| 저자 |
홍웅길1, 안준혁1, 정경원2, 박준규3, 심왕근1, 나재운1
|
| 소속 |
1순천대, 2조선이공대, 3(주)시지바이오 |
| 키워드 |
Tropolone; Chitosan; Nanoparticle; Sustained release
|
| E-Mail |
|
