| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation and Characterization of Flufenamic acid-loaded Lauric acid–g-chitosan nanoparticle |
| 초록 |
Flufenamic acid (FA) has anticancer effect against bladder cancer cell. However, solubility of FA against water is very low, which may lead to inefficient anticancer effect. To overcome these obstacle, many of researchers have designed to polymeric micelles composed of hydrophilic and hydrophobic substance in order to deliver insoluble drug at cancer cell. We used to lauric acid (LA) and it was grafted of water chitosan (WC) by coupling agent. Chemical structure of LWC was confirmed by 1H-NMR and FT-IR. Its critical aggregation concentration (CAC) was analyzed by fluorophotometer. In addition, FA-loaded LWC (LWCF) nanoparticles were produced by dialysis method. Its drug contents (DC) and encapsulation efficiency (EE) from LWCF were calculated by using UV-vis spectrophotometer. Moreover, cytotoxicity and anticancer activity were conducted by using MTT assay. These results suggest that it can be applied to anticancer agent against bladder cancer cell. |
| 저자 |
안준혁1, 홍웅길1, 정경원2, 김태훈3, 심왕근1, 나재운1
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| 소속 |
1순천대, 2조선이공대, 3CGBio |
| 키워드 |
Water chitosan; flufenamic acid; anticancer effect
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| E-Mail |
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