| 초록 |
To date, diverse nanoparticle systems have been developed to amplify intracellular oxidative stress for cancer-specific therapy. Compared to normal cells, cancer cells are known for upregulated reactive oxygen species (ROS) levels. Hence, the modulation of the ROS level in cancer cells has been a research target of great interest for cancer treatment. Herein, we demonstrated a biomineral-based oxidative stress-amplifying nanoparticle that can effectively kill the cancer cells through the Fenton reaction. Nano-hydroxyapatite doped with Cu2+ and arsenite (CuAS-nHAp) was fabricated through an aqueous one-pot in situ process. CuAS-nHAp can amplify oxidative stress by the AS-induced elevation of the hydrogen peroxide level and the subsequent Fenton reaction which produces hydroxyl radicals. CuAs-nHAp, in the endosomal pH, would simultaneously release Cu2+ and AS ions to amplify the intracellular ROS level. This nanoparticle would act as a novel ROS-controlling agent for cancer therapy. |
