| 초록 |
Poly(acrylic acid) (PAA) hydrogels are widely used in drug delivery patches because hydrogels have excellent ionic conductivity, adhesion and biocompatibility. However, PAA have disadvantages low durability and weak mechanical properties. Silicone has excellent mechanical properties and heat resistance, and is widely utilized in medical materials. However, silicone does not exhibit conductivity. In this study, the PAA-silicone hydrogels were prepared using electron-beam irradiation. The PAA-silicone hydrogel has excellent biocompatibility and mechanical properties with a good ionic conductivity. Specifically, the tensile strength increased more than 3.5 times. It was confirmed using a Franz cell that the amount of drug released from a drug-loaded PAA-silicone hydrogel was maximized by an electrical stimulus. |
