| 초록 |
Zwitterion, which have both positive and negative charge groups, can form hydration layer within the water solution by adjusting pH. If zwitterion is formed on particle surfaces, the foreign body recognition system can be prevented with the same effect as PEGylation, thus can play a role as a biocompatible drug carrier. Therefore, we functionalized silica nanoparticle (SiNP) with amine group by using (3-Aminopropyl)triethoxysiliane (APTES). Then 1,3-Propanesultone (PS) was used to form sulfobetaine zwitterion on amine functionalized SiNP surfaces. Formation of sulfobetaine group was verified by using raman spectroscopy, and the proper pH of the synthesized Zwitterion NP (ZwitNP) was verified with QCM. As a drug carrier, ZwitNP contains secondary amine group in the structure, so ZwitNP can load and release nitric oxide (NO) which is gas molecule drug. Furthermore, it was also confirmed that by adjusting pH of NO-loaded ZwitNP solution, controlling the release rate of NO is possible. |
