| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Enhanced cancer chemo-immunotherapy using nanomicelle generating microneedles containing paclitaxel and TLR7/8 agonist |
| 초록 |
A dissolving microneedle(MN) for transdermal drug delivery is an attractive method to improve therapeutic efficacy. Efficient delivery of low dose chemotherapeutic agent-paclitaxel and immunostimulatory adjuvants-resiquimod was synergized to demonstrate tumor killing effect and activation of antigen presenting cells. In this research, both therapeutic agents being water insoluble were dispersed with the help of amphiphilic triblock copolymer: Pluronic F127 based dissolving MNs in situ that generate nanomicells (NMCs) upon their dissolution after cutaneous application. Various Cancer cells were significantly killed via paclitaxel and combination of paclitaxel and resiquimod in vitro, while antigen presenting cells (dendritic cells) treated with same concentration of resiquimod along with the combination led to enhanced proliferation. In DCs, as to extraordinarily enhanced secretion of pro-inflammatory, the combination resulted in a considerable synergy effect for the immune responses. |
| 저자 |
정재백, 정지훈, 김다훤, 임수연, 조희주, 김동민
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| 소속 |
성균관대 |
| 키워드 |
Dissolving microneedle; Nanomicelle; Toll-like receptor agonist; Combination therapy; Chemotherapy
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| E-Mail |
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